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ID: ALA1135278
Journal: Bioorg Med Chem Lett
Title: Thiophene derivatives: a new series of potent norepinephrine and serotonin reuptake inhibitors.
Authors: Zhang A, Zhou G, Rong SB, Johnson KM, Zhang M, Kozikowski AP.
Abstract: A series of (1S,3S,6R,10S)-(Z)-9-(thienylmethylene- or substituted thienylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes was prepared and evaluated for the ability to block dopamine, serotonin, and norepinephrine reuptake by their respective transporters. Compound 5b is a NET-selective inhibitor, 5c is a mixed NET- and SERT-selective inhibitor, while 11 is a SERT-selective inhibitor.
CiteXplore: 11909701