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ID: ALA1135305
Journal: Bioorg Med Chem Lett
Title: Enantiospecific, selective cyclooxygenase-2 inhibitors.
Authors: Kozak KR, Prusakiewicz JJ, Rowlinson SW, Marnett LJ.
Abstract: Cyclooxygenase inhibition studies with novel indomethacin alkanolamides demonstrate the potential for dramatic differences in inhibitor properties conferred by subtle structural modifications. The transformation of non-selective alpha-(S)-substituted indomethacin ethanolamides to potent, COX-2 selective inhibitors by simple stereocenter inversion highlights this property.
CiteXplore: 11965379