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ID: ALA1135315

Journal: Bioorg Med Chem Lett

Title: Spirocyclic NK(1) antagonists I: [4.5] and [5.5]-spiroketals.

Authors: Seward EM, Carlson E, Harrison T, Haworth KR, Herbert R, Kelleher FJ, Kurtz MM, Moseley J, Owen SN, Owens AP, Sadowski SJ, Swain CJ, Williams BJ.

Abstract: A series of novel spiroketal-based NK(1) antagonists is described. The effect of modifications to the spiroether ring and aromatic substituents are discussed, leading to the identification of compounds with high affinity and excellent CNS penetration.

CiteXplore: 12182850

DOI: 10.1016/s0960-894x(02)00506-1