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ID: ALA1135342
Journal: Bioorg Med Chem Lett
Title: Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Authors: Vanheusden V, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S.
Abstract: A number of 2'- and 3'-modified thymidine 5'-O-monophosphate analogues were synthesized as potential leads for new anti-mycobacterial drugs. Evaluation of their affinity for Mycobacterium tuberculosis thymidine monophosphate kinase showed that a 2'-halogeno substituent and a 3'-azido function are the most favorable leads for further development of potent inhibitors of this enzyme.
CiteXplore: 12217356