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ID: ALA1135347
Journal: Bioorg Med Chem Lett
Title: Spirocyclic NK(1) antagonists II: [4.5]-spiroethers.
Authors: Williams BJ, Cascieri MA, Chicchi GG, Harrison T, Owens AP, Owen SN, Rupniak NM, Tattersall DF, Williams A, Swain CJ.
Abstract: A series of novel spiroether-based neurokinin-1 (NK(1)) antagonists is described. The effect of modifications to the spiroether ring and aromatic substituents are discussed, leading to the identification of compounds with high affinity and excellent CNS penetration.
CiteXplore: 12217362