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ID: ALA1135352
Journal: Bioorg Med Chem Lett
Title: 8-Anilinoimidazo[4,5-g]quinoline-7-carbonitriles as Src kinase inhibitors.
Authors: Berger D, Dutia M, Powell D, Wu B, Wissner A, DeMorin F, Weber J, Boschelli F.
Abstract: A series of 8-anilinoimidazo[4,5-g]quinoline-7-carbonitriles was synthesized and evaluated as Src kinase inhibitors. Several aniline substituents were surveyed, as well as water-solubilizing groups at the C-2 and N-3 positions. Potent Src inhibitors were identified, with N-3 providing the best position for an additional water-solubilizing group.
CiteXplore: 12217371