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ID: ALA1135365

Journal: Bioorg Med Chem Lett

Title: Mixed lineage kinase activity of indolocarbazole analogues.

Authors: Murakata C, Kaneko M, Gessner G, Angeles TS, Ator MA, O'Kane TM, McKenna BA, Thomas BA, Mathiasen JR, Saporito MS, Bozyczko-Coyne D, Hudkins RL.

Abstract: The MLK1-3 activity for a series of analogues of the indolocarbazole K-252a is reported. Addition of 3,9-bis-alkylthiomethyl groups to K-252a results in potent and selective MLK inhibitors. The in vitro and in vivo survival promoting activity of bis-isopropylthiomethyl-K-252a (16, CEP-11004/KT-8138) is reported.

CiteXplore: 11755341

DOI: 10.1016/s0960-894x(01)00690-4