Basic Information
ID: ALA1135373
Journal: Bioorg Med Chem Lett
Title: Biphenyls as potent vitronectin receptor antagonists.
Authors: Urbahns K, Härter M, Albers M, Schmidt D, Stelte-Ludwig B, Brüggemeier U, Vaupel A, Gerdes C.
Abstract: Vitronectin receptor (alpha(V)beta(3)) antagonism has been implicated as a mechanism for the treatment of restenosis following balloon angioplasty. In this work we present results from screening of a focused combinatorial library based on a biphenyl moiety. Our SAR studies led to the identification of compounds with subnanomolar activity, selectivity towards the related GPIIbIIIa receptor and functional activity on human smooth muscle cell migration.
CiteXplore: 11755355
DOI: 10.1016/s0960-894x(01)00717-x
Patent ID: ┄
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