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ID: ALA1135383
Journal: Bioorg Med Chem Lett
Title: Increase of the adenallene anti-HIV activity in cell culture using its bis(tBuSATE) phosphotriester derivative.
Authors: Egron D, Périgaud C, Gosselin G, Aubertin AM, Gatanaga H, Mitsuya H, Zemlicka J, Imbach JL.
Abstract: The bis(S-pivaloyl-2-thioethyl) phosphotriester derivative of 9-(4'-hydroxy-1',2'-butadienyl)adenine (adenallene) was synthesized. This mononucleotide prodrug proved to be more effective than the parent nucleoside in inhibiting HIV-1 replication in several human T4 lymphoblastoid cell lines.
CiteXplore: 11755368