Document Report Card
Basic Information
ID: ALA1135387
Journal: Bioorg Med Chem Lett
Title: Synthesis and kinase inhibitory activity of 3'-(S)-epi-K-252a.
Authors: Gingrich DE, Hudkins RL.
Abstract: The 3'-epi diastereomer of K-252a was synthesized with the goal of evaluating the stereochemical requirements of the 3'-sugar alcohol on kinase inhibitory activity. Inverting the 3'-alcohol resulted in a 20 nM inhibitor of VEGFR2 and a 1 nM inhibitor of TrkA tyrosine kinase.
CiteXplore: 12270156