Document Report Card

ID: ALA1135491

Journal: J Med Chem

Title: Novel 2-oxoamide inhibitors of human group IVA phospholipase A(2).

Authors: Kokotos G, Kotsovolou S, Six DA, Constantinou-Kokotou V, Beltzner CC, Dennis EA.

Abstract: A novel class of potent human cytosolic phospholipase A(2) (GIVA PLA(2)) inhibitors was developed. These inhibitors were designed to contain the 2-oxoamide functionality and a free carboxyl group. Among the compounds tested, a long-chain 2-oxoamide containing L-gamma-norleucine was the most potent inhibitor, causing a 50% decrease in GIVA PLA(2) activity at 0.009 mole fraction.

CiteXplore: 12086476

DOI: 10.1021/jm025538p