Basic Information
ID: ALA1135597
Journal: J Med Chem
Title: A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity.
Authors: Guenther S, Balzarini J, De Clercq E, Nair V.
Abstract: (E)-5-(2-Bromovinyl)isodideoxyuridine (BVisoDDU), synthesized on the basis of molecular modeling, is selectively active against HSV-1 (three different strains) but inactive against HSV-2. Unlike BVDU, BVisoDDU is completely resistant to cleavage by thymidine phosphorylase. BVisoDDU is also the first nucleoside analogue lacking OH groups at both the 2'- and 3'-position that shows pronounced activity against HSV-1 replication.
CiteXplore: 12459010
DOI: 10.1021/jm025569k
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets