Document Report Card

ID: ALA1135617

Journal: J Med Chem

Title: Dicarboxylic acid bis(L-prolyl-pyrrolidine) amides as prolyl oligopeptidase inhibitors.

Authors: Wallén EA, Christiaans JA, Forsberg MM, Venäläinen JI, Männistö PT, Gynther J.

Abstract: New dicarboxylic acid bis(L-prolyl-pyrrolidine) amides were synthesized, and their inhibitory activity against prolyl oligopeptidase from pig brain was tested in vitro. As compared with earlier described prolyl oligopeptidase inhibitors, these new compounds have in common an L-prolyl-pyrrolidine moiety, but the typical lipophilic acyl end group is replaced by another L-prolyl-pyrrolidine moiety connected symmetrically with a short dicarboxylic acid linker. These compounds are a new type of peptidomimetic prolyl oligopeptidase inhibitor.

CiteXplore: 12238937

DOI: 10.1021/jm020966g