Document Report Card

ID: ALA1135697

Journal: J Med Chem

Title: Formaldehyde-induced DNA cross-link of indolizino[1,2-b]quinolines derived from the A-D rings of camptothecin.

Authors: Perzyna A, Marty C, Facompré M, Goossens JF, Pommery N, Colson P, Houssier C, Houssin R, Hénichart JP, Bailly C.

Abstract: Camptothecin consists of a lactone E ring adjacent to tetracyclic A-D rings of a planar chromophore, which are essential for topoisomerase I inhibition and DNA interaction. The A-D rings can be exploited to develop DNA-sequence-reading molecules. Indolizino[1,2-b]quinoline derivatives substituted with a piperidinoethyloxy side chain and an aminomethyl function on rings A and D, respectively, were synthesized, and their DNA binding and formaldehyde-mediated bonding properties were investigated.

CiteXplore: 12477365

DOI: 10.1021/jm020235g