Pyrazolopyrimidine-2,4-dione sulfonamides: novel and selective calcitonin inducers.
Basic Information
ID: ALA1135752
Journal: J Med Chem
Title: Pyrazolopyrimidine-2,4-dione sulfonamides: novel and selective calcitonin inducers.
Authors: Gilbert AM, Caltabiano S, Koehn FE, Chen ZJ, Francisco GD, Ellingboe JW, Kharode Y, Mangine A, Francis R, TrailSmith M, Gralnick D.
Abstract: A series of pyrazolo[4,3-d]pyrimidine sulfonamides and pyrazolo[3,4-d]pyrimidine sulfonamides have been synthesized. These compounds increase transcription of a calcitonin-luciferase promoter and production of cellular calcitonin in a calcitonin-secretion/RIA assay with minimized phosphodiesterase type 4 inhibitory activity at 30 microM as compared to structurally related xanthine methylene ketones such as denbufyllene. These two series are notable examples of small molecules that act as CT-inducers, a method to potentially treat bone loss diseases.
CiteXplore: 12014973
DOI: 10.1021/jm010554s
Patent ID: ┄