Document Report Card

ID: ALA1135818

Journal: J Med Chem

Title: A new, potent urotensin II receptor peptide agonist containing a Pen residue at the disulfide bridge.

Authors: Grieco P, Carotenuto A, Campiglia P, Zampelli E, Patacchini R, Maggi CA, Novellino E, Rovero P.

Abstract: Replacing Cys(5) by Pen (penicillamine, beta,beta-dimethylcysteine) in the cyclic C-terminal U-II octapeptide, U-II(4-11), we have obtained a potent urotensin II (U-II) receptor agonist. Conformational analysis of solution NMR data indicated that the putative biologically active conformation of U-II is stabilized by introduction of a Pen residue. To the best of our knowledge, this is the most potent U-II receptor agonist reported to date.

CiteXplore: 12238917

DOI: 10.1021/jm025549i