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ID: ALA1135848
Journal: Bioorg Med Chem Lett
Title: Novel substituted 4-aminomethylpiperidines as potent and selective human beta3-agonists. Part 2: arylethanolaminomethylpiperidines.
Authors: Steffan RJ, Ashwell MA, Solvibile WR, Matelan E, Largis E, Han S, Tillet J, Mulvey R.
Abstract: The synthesis and SAR of a series of beta3 adrenoreceptor agonists based on a novel template derived from 4-aminomethylpiperidine coupled with a common pharmacophore, arylethylamine, is described. This combination led to the identification of human beta3 adrenoreceptor agonists with in vivo activity in a transgenic mouse model.
CiteXplore: 12270184