Document Report Card
Basic Information
ID: ALA1135853
Journal: Bioorg Med Chem Lett
Title: Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the metal binding group.
Authors: Smith HK, Beckett RP, Clements JM, Doel S, East SP, Launchbury SB, Pratt LM, Spavold ZM, Thomas W, Todd RS, Whittaker M.
Abstract: A series of analogues of the potent peptide deformylase (PDF) inhibitor BB-3497 containing alternative metal binding groups was synthesised. Enzyme inhibition and antibacterial activity data for these compounds revealed that the bidentate hydroxamic acid and N-formyl hydroxylamine structural motifs represent the optimum chelating groups on the pseudopeptidic BB-3497 backbone.
CiteXplore: 12443784