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ID: ALA1135857
Journal: Bioorg Med Chem Lett
Title: Exploration of peptidyl hydrazones as water-soluble calpain inhibitors.
Authors: Nakamura M, Inoue J.
Abstract: A series of peptidyl hydrazones was synthesized, and their inhibitory activity against mu-calpain and water-solubility were measured. Among these compounds, N,N-dimethyl glycyl hydrazone 6, which inhibited mu-calpain with IC(50) of 0.37 microM, possessed the appropriate water-solubility. Furthermore, hydrazone 6 was found to possess the excellent in vitro metabolic stability.
CiteXplore: 12039572