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ID: ALA1135870
Journal: Bioorg Med Chem Lett
Title: 4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.
Authors: Pinard E, Alanine A, Bourson A, Büttelmann B, Heitz M, Mutela Ramanjit Gill V, Trube G, Wyler R.
Abstract: Screening of the Roche compound library led to the identification of 4-aminoquinoline 4 as structurally novel NR1/2B subtype selective NMDA receptor antagonist. The SAR which was developed in this series resulted in the discovery of highly potent and in vivo active blockers.
CiteXplore: 12182873