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ID: ALA1135947

Journal: Bioorg Med Chem Lett

Title: Structure-based design and synthesis of HIV-1 protease inhibitors employing beta-D-mannopyranoside scaffolds.

Authors: Murphy PV, O'Brien JL, Gorey-Feret LJ, Smith AB.

Abstract: A preliminary account on the structure-based design, synthesis and evaluation of peptidomimetic inhibitors of HIV-1 protease containing beta-D-mannopyranoside scaffolds is given. The compounds prepared had IC(50) values in the micromolar range. The results provide a platform for the development of more potent carbohydrate-based inhibitors of HIV-1 and other aspartic proteases.

CiteXplore: 12067556

DOI: 10.1016/s0960-894x(02)00220-2