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ID: ALA1135949
Journal: Bioorg Med Chem Lett
Title: Pyrrolylquinoxalinediones carrying a piperazine residue represent highly potent and selective ligands to the homomeric kainate receptor GluR5.
Authors: Lubisch W, Behl B, Henn C, Hofmann HP, Reeb J, Regner F, Vierling M.
Abstract: Pyrrolylquinoxalinediones carrying aminoalkyl residues were evaluated for affinity to the recombinant, homomeric kainate receptors GluR5, GluR6 and GluR7. Most derivatives preferred binding to GluR5. In particular, the piperazine 6e represents a highly potent and selective antagonist to GluR5.
CiteXplore: 12127516