Synthesis and vasorelaxant activity of new coumarin and furocoumarin derivatives.
Basic Information
ID: ALA1135963
Journal: Bioorg Med Chem Lett
Title: Synthesis and vasorelaxant activity of new coumarin and furocoumarin derivatives.
Authors: Campos-Toimil M, Orallo F, Santana L, Uriarte E.
Abstract: We have synthesized a new series of coumarins and furocoumarins and evaluated their vasorelaxant activity in rat aorta rings pre-contracted with noradrenaline or by depolarisation with high KCl. The new furocoumarins relax smooth vascular muscle with a profile similar to that of khellin (a furochromone that directly relaxes smooth muscle) and at a greater potency, suggesting that these compounds have a potential interest for the development of new and more efficient vasodilator drugs.
CiteXplore: 11859002
DOI: 10.1016/s0960-894x(02)00015-x
Patent ID: ┄