Document Report Card
Basic Information
ID: ALA1136020
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug.
Authors: Berry JM, Howard PW, Kelland LR, Thurston DE.
Abstract: The first example of an N10-protected (e.g., Psec, 15) pyrrolo[2,1-c][1,4]benzodiazepine (PBD) analogue that retains significant cytotoxicity in a number of tumour cell lines is reported. This prototype could lead to a new generation of clinically useful N10-protected PBD prodrugs.
CiteXplore: 11992788