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ID: ALA1136033
Journal: Bioorg Med Chem Lett
Title: Effects of the incorporation of IBTM beta-turn mimetics into the dipeptoid CCK(1) receptor agonist PD 170292.
Authors: Martín-Martínez M, Latorre M, García-López MT, Cenarruzabeitia E, Del Río J, González-Muñiz R.
Abstract: Replacement of the 2-Adoc-D-alphaMeTrp residue in the non-selective CCK(1) receptor agonist PD 170292 by the Z-(2R,5R,11bS)-IBTM skeleton, able to fix a type II beta-turn-like conformation, led to a conformationally restricted dipeptoid analogue, namely 3a, which exhibited a notable increase in the CCK(1) selectivity and antagonist properties.
CiteXplore: 11755332