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ID: ALA1136034
Journal: Bioorg Med Chem Lett
Title: Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 1: 2-Pyridinylguanidines.
Authors: Barber CG, Dickinson RP, Horne VA.
Abstract: The identification of 2-pyridinylguanidines (e.g., 27 and 28) as selective inhibitors of urokinase-type plasminogen activator (uPA) is described. The X-ray crystal structure of 27 has been determined, and modelling has been used to predict binding in the enzyme active site.
CiteXplore: 11755349