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ID: ALA1136036
Journal: Bioorg Med Chem Lett
Title: Targeting thrombin and factor VIIa: design, synthesis, and inhibitory activity of functionally relevant indolizidinones.
Authors: Hanessian S, Therrien E, Granberg K, Nilsson I.
Abstract: Guided by molecular modeling, docking experiments, and available X-ray crystal structure data on the serine protease Factor VIIa and thrombin, a series of indolizidinone derivatives was designed and synthesized having diverse functionality at the P1, P2, and P3 sites.
CiteXplore: 12270173