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ID: ALA1136057
Journal: Bioorg Med Chem Lett
Title: Design, synthesis and biological activity of novel C2-C3' N-Linked macrocyclic taxoids.
Authors: Ojima I, Geng X, Lin S, Pera P, Bernacki RJ.
Abstract: A series of novel macrocyclic taxoids was designed and synthesized by connecting the C-2 and C-3' N positions of the taxoid framework with various tethers. Cytotoxicity of these macrocyclic taxoids was evaluated against a human breast cancer cell line LCC6-WT, and a couple of the taxoids exhibited 0.09-0.3 microM IC(50) values.
CiteXplore: 11814794