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ID: ALA1136058
Journal: Bioorg Med Chem Lett
Title: 4-Anilino-3-cyanobenzo[g]quinolines as kinase inhibitors.
Authors: Zhang N, Wu B, Wissner A, Powell DW, Rabindran SK, Kohler C, Boschelli F.
Abstract: A series of 4-anilino-3-cyanobenzo[g]quinolines was prepared as potent kinase inhibitors. Compared with their bicyclic 4-anilino-3-cyanoquinoline analogues, the tricyclic 4-anilino-3-cyanobenzo[g]quinolines are less active against EGF-R kinase, equally active against MAPK kinase (MEK), and more active against Src kinase. For Src kinase inhibition, the best activity is obtained when both the 7- and 8-positions are substituted with alkoxy groups. Several of these kinase inhibitors show potent growth inhibitory activity in tumor cells.
CiteXplore: 11814812