Basic Information
ID: ALA1136060
Journal: Bioorg Med Chem Lett
Title: A new class of type I protein geranylgeranyltransferase (GGTase I) inhibitor.
Authors: Sunami S, Ohkubo M, Sagara T, Ono J, Asahi S, Koito S, Morishima H.
Abstract: Replacement of the thiol groups in 1, a potent and highly selective Candida albicans GGTase I inhibitor discovered through screening, with an imidazole ring was achieved by using solid phase synthesis. A non-thiol compound, 7, was found as a representative of a new class of potent C. albicans GGTase I inhibitor with high selectivity against human GGTase I.
CiteXplore: 11844687
DOI: 10.1016/s0960-894x(01)00813-7
Patent ID: ┄
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