Document Report Card
Basic Information
ID: ALA1136063
Journal: Bioorg Med Chem Lett
Title: Oxal hydroxamic acid derivatives with inhibitory activity against matrix metalloproteinases.
Authors: Krumme D, Tschesche H.
Abstract: Several amines, amino acid derivatives and low molecular weight peptides containing an amide-bound oxal hydroxamic acid moiety have been synthesized and tested for their inhibitory effects towards native human gelatinase B (MMP-9) and the catalytic domains of the membrane type MT1-MMP (MMP-14) and of neutrophil collagenase (MMP-8). A number of these compounds exhibited considerable inhibitory activity against the tested metalloproteinases.
CiteXplore: 11958997