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ID: ALA1136090
Journal: Bioorg Med Chem Lett
Title: Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors.
Authors: Finn J, Mattia K, Morytko M, Ram S, Yang Y, Wu X, Mak E, Gallant P, Keith D.
Abstract: Starting with a micromolar lead identified from high-throughput screening, a series of pyrazoles were discovered with significantly improved potency on bacterial methionyl-tRNA synthetase and selectivity over human methionyl-tRNA synthetase.
CiteXplore: 12798340