Document Report Card
Basic Information
ID: ALA1136097
Journal: Bioorg Med Chem Lett
Title: Synthesis of the first examples of A-C8/C-C2 amide-Linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.
Authors: Gregson SJ, Howard PW, Thurston DE.
Abstract: We report the synthesis of novel A-C8/C-C2 amide-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers (4a and 4b) via convergent routes. These compounds lack the potent DNA interstrand cross-linking ability and resultant pronounced cytotoxicity of the known A-C8/A-C8' linked dimers (e.g., 2a-b).
CiteXplore: 12824017