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ID: ALA1136120
Journal: Bioorg Med Chem Lett
Title: Effect of catechol derivatives on cell growth and lipoxygenase activity.
Authors: Simpson J, Forrester R, Tisdale MJ, Billington DC, Rathbone DL.
Abstract: Derivatives of salicylic acid have been synthesized as potential lipoxygenase inhibitors. Agents containing a phenolic dihydroxy moiety showed potent (IC(50)10(-6)-10(-7) M) inhibition of the growth of murine colonic tumour cells in vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in intact cells. The catechols were also potent inhibitors of rabbit reticulocyte 15-lipoxygenase (IC(50) approximately 1 microM).
CiteXplore: 12852938