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ID: ALA1136124
Journal: Bioorg Med Chem Lett
Title: Copper complex of hydroxyl-substituted triazamacrocyclic ligand and its antitumor activity.
Authors: Liang F, Wu C, Lin H, Li T, Gao D, Li Z, Wei J, Zheng C, Sun M.
Abstract: The protonation constants and the stability constants for the formation of copper (II) complex of the ligand [1,4,7] Triazecan-9-ol (L) were presented. Antitumor activity of CuL complex was reported. Preliminary pharmacological tests showed that it had antitumor activity against HXO-RB44 and BEL-7402 cell lines in vitro. Nuclei of [CuL]-stimulated BEL-7402 cells clearly exhibited condensation and break down into chromatin clumps typical of apoptosis. Also it exhibited perturbation effects to BEL-7402 cell lines cycle and further studies showed that it could cleave supercoiled DNA (pBR 322) to nicked and linear DNA.
CiteXplore: 12852945