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ID: ALA1136143
Journal: Bioorg Med Chem Lett
Title: Synthesis and activity of novel benzoxazole derivatives of mannopeptimycin glycopeptide antibiotics.
Authors: Sum PE, How D, Torres N, Newman H, Petersen PJ, Mansour TS.
Abstract: A series of benzoxazole derivatives of the mannopeptimycin glycopeptide antibiotics was synthesized via a novel benzoxazole formation reaction by treating aminophenol of mannopeptimycin-beta with an aldehyde and DDQ in DMF. Some of these derivatives (e.g., 5b, 5d, 5m, and 7b) showed good activity against Gram-(+) bacteria when compared to the parent compound mannopeptimycin-beta.
CiteXplore: 12852976