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ID: ALA1136185
Journal: Bioorg Med Chem Lett
Title: Linearized and truncated microcystin analogues as inhibitors of protein phosphatases 1 and 2A.
Authors: Gulledge BM, Aggen JB, Chamberlin AR.
Abstract: A series of acyclic, truncated microcystin analogues, comprised of the dienic beta-amino acid (Adda) and up to four additional amino acids characteristic of the parent toxin, was synthesized and screened for activity as inhibitors of PP1 and PP2A. Despite a recent report to the contrary for a microcystin-derived tetrapeptide degradation product, none approaches the potency of microcystin itself.
CiteXplore: 14611854