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ID: ALA1136186
Journal: Bioorg Med Chem Lett
Title: Microcystin analogues comprised only of Adda and a single additional amino acid retain moderate activity as PP1/PP2A inhibitors.
Authors: Gulledge BM, Aggen JB, Eng H, Sweimeh K, Chamberlin AR.
Abstract: A series of greatly simplified microcystin analogues comprised only of Adda (the beta-amino acid common to the microcystins, nodularins, and motuporin,) and a single additional amino acid residue was synthesized and screened for inhibition of the protein phosphatases 1 and 2A. Several of the analogues were shown to be mid-nanomolar inhibitors of the enzymes.
CiteXplore: 14611855