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ID: ALA1136200
Journal: Bioorg Med Chem Lett
Title: Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. Part 4: structure-activity relationships for substituents on the quinazoline moiety of 4-[4-(N-substituted(thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives.
Authors: Matsuno K, Seishi T, Nakajima T, Ichimura M, Giese NA, Yu JC, Oda S, Nomoto Y.
Abstract: Here, we investigated the structure-activity relationships of the 6,7-dimethoxyquinazoline moiety. With regard to exploration of positions and varieties of substituents on the quinazoline ring, 6,7-dialkoxy substitution was optimal. This study suggests the possibility of further modifications for this moiety.
CiteXplore: 12941321