Design of quinolinedione-based geldanamycin analogues.

ID: ALA1136211

Journal: Bioorg Med Chem Lett

Title: Design of quinolinedione-based geldanamycin analogues.

Authors: Hargreaves R, David CL, Whitesell L, Skibo EB.

Abstract: Quinoline-5,8-dione-based compounds were designed from the structure of the geldanamycin-bound Hsp-90 active site. The active site model predicted that aromatic substituents should be present at the 2-position, to take advantage of a hydrophobic pocket, and amino substituents should be present at the 6- or 7-position. COMPARE analysis revealed that the LC(50) profile of 2-phenyl-6-(2-chloroethylamino)quinoline-5,8-dione has the highest geldanamycin-like activity (0.74 correlation coefficient).

CiteXplore: 12941337

DOI: 10.1016/s0960-894x(03)00650-4

Patent ID: ┄