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ID: ALA1136219
Journal: Bioorg Med Chem Lett
Title: Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents.
Authors: Beebe X, Nilius AM, Merta PJ, Soni NB, Bui MH, Wagner R, Beutel BA.
Abstract: The parallel synthesis and antibacterial activity of 5-hydroxy[1,2,5] oxadiazolo[3,4-b]pyrazines is reported. The compounds were synthesized by condensing diaminofurazan with alpha-keto acids to give a variety of aryl-substituted analogues. Halogenated phenyl groups at C-6 give rise to the greatest Haemophilus influenzae antibacterial activity.
CiteXplore: 12951079