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ID: ALA1136220
Journal: Bioorg Med Chem Lett
Title: Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives.
Authors: You YJ, Kim Y, Nam NH, Ahn BZ.
Abstract: New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at C2 showed strong cytotoxicity.
CiteXplore: 12951080