Document Report Card
Basic Information
ID: ALA1136224
Journal: Bioorg Med Chem Lett
Title: De novo synthesis of two new cytotoxic tiazofurin analogues with modified sugar moieties.
Authors: Popsavin M, Torović L, Kojić V, Bogdanović G, Spaić S, Popsavin V.
Abstract: A divergent synthesis of two novel tiazofurin analogues, 2-(3-deoxy-3-fluoro-beta-D-xylofuranosyl)thiazole-4-carboxamide (2) and 2-(3-acetamido-3-deoxy-beta-D-xylofuranosyl)thiazole-4-carboxamide (3), has been achieved starting from D-glucose. Both nucleoside analogues were evaluated for their in vitro cytotoxicity against several human leukaemia and solid tumour cell lines.
CiteXplore: 12951086