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ID: ALA1136228
Journal: Bioorg Med Chem Lett
Title: O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists.
Authors: Adams AD, Hu Z, von Langen D, Dadiz A, Elbrecht A, MacNaul KL, Berger JP, Zhou G, Doebber TW, Meurer R, Forrest MJ, Moller DE, Jones AB.
Abstract: A new class of O-arylmandelic acid PPAR agonists show excellent anti-hyperglycemic efficacy in a db/db mouse model of DM2. These PPARalpha-weighted agonists do not show the typical PPARgamma associated side effects of BAT proliferation and cardiac hypertrophy in a rat tolerability assay.
CiteXplore: 12951090