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ID: ALA1136231
Journal: Bioorg Med Chem Lett
Title: Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents.
Authors: Lam T, Ling T, Chowdhury C, Chao TH, Bahjat FR, Lloyd GK, Moldawer LL, Palladino MA, Theodorakis EA.
Abstract: The synthesis and biological evaluation of a new family of diterpenes, represented by structures 2 and 3, is presented. These compounds constitute isomeric analogues of acanthoic acid (1) and were examined as potent anti-inflammatory agents. Among them, methyl ester 12 exhibited a low non-specific cytotoxicity, inhibited TNF-alpha synthesis and displayed good specificity in suppressing cytokine expression.
CiteXplore: 12951096