Cyclohexanedione herbicides are inhibitors of rat heart acetyl-CoA carboxylase.
Basic Information
ID: ALA1136234
Journal: Bioorg Med Chem Lett
Title: Cyclohexanedione herbicides are inhibitors of rat heart acetyl-CoA carboxylase.
Authors: Seng TW, Skillman TR, Yang N, Hammond C.
Abstract: Acetyl CoA carboxylase (ACC) catalyzes the carboxylation of acetyl CoA to form malonyl CoA. In skeletal muscle and heart, malonyl CoA functions to regulate lipid oxidation by inhibition of carnitine palmitoyltransferase-1, an enzyme which controls the entry of long chain fatty acids into mitochondria. We have found that several members of the cyclohexanedione class of herbicides are competitive inhibitors of rat heart ACC. These compounds constitute valuable reagents for drug development and the study of ACCbeta, a validated anti-obesity target.
CiteXplore: 12951100
DOI: 10.1016/s0960-894x(03)00664-4
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