2-piperidin-4-yl-benzimidazoles with broad spectrum antibacterial activities.

ID: ALA1136237

Journal: Bioorg Med Chem Lett

Title: 2-piperidin-4-yl-benzimidazoles with broad spectrum antibacterial activities.

Authors: He Y, Wu B, Yang J, Robinson D, Risen L, Ranken R, Blyn L, Sheng S, Swayze EE.

Abstract: A series of 2-piperidin-4-yl-benzimidazoles were synthesized and evaluated for antibacterial activities. Certain compounds inhibit bacterial growth with low micromolar minimal inhibitory concentration (MIC). These benzimidazoles are effective against both Gram-positive and Gram-negative bacteria of clinical importance, particularly enterococci, and represent a new class of potential antibacterial agents.

CiteXplore: 12951103

DOI: 10.1016/s0960-894x(03)00661-9

Patent ID: ┄