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ID: ALA1136239
Journal: Bioorg Med Chem Lett
Title: Bicyclo[2.2.1]heptanes as novel triple re-uptake inhibitors for the treatment of depression.
Authors: Axford L, Boot JR, Hotten TM, Keenan M, Martin FM, Milutinovic S, Moore NA, O'Neill MF, Pullar IA, Tupper DE, Van Belle KR, Vivien V.
Abstract: A series of substituted naphthyl containing chiral [2.2.1] bicycloheptanes were prepared utilizing asymmetric Diels-Alder chemistry. This paper describes structure-activity relationships in this series. The N-methyl 2-naphthyl analogue (16d) and its des-methyl analogue (17d) are active triple re-uptake inhibitors both in vivo and in vitro.
CiteXplore: 12951108