Document Report Card

Basic Information

ID: ALA1136251

Journal: Bioorg Med Chem Lett

Title: Synthesis and biological evaluation of menthol-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1).

Authors: Ye B, Bauer S, Buckman BO, Ghannam A, Griedel BD, Khim SK, Lee W, Sacchi KL, Shaw KJ, Liang A, Wu Q, Zhao Z.

Abstract: Compound 1 was identified by high throughput screening as a novel PAI-1 inhibitor. Optimization of the B and C-segments of 1 resulted in a series of structurally simplified compounds with improved potency. The synthesis and SAR data of these compounds are presented here.

CiteXplore: 12951126

DOI: 10.1016/s0960-894x(03)00686-3