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ID: ALA1136264
Journal: Bioorg Med Chem Lett
Title: Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors.
Authors: Lim HS, Oh YS, Suh PG, Chung SK.
Abstract: Sphingosine-1-phosphate (S1P) is considered to be an important regulator of diverse biological processes acting as a natural ligand to EDG receptors. As a preliminary study to develop potent and selective agonist and antagonist for EDG receptors, we report synthesis of S1P stereoisomers and analogues and their binding affinities to EDG-1, -3, and -5.
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